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KMID : 1011320180100010036
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Journal of Pharmacoepidemiology and Risk Management
2018 Volume.10 No. 1 p.36 ~ p.39
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A Case of Teicoplanin-Induced Neutropenia in Patients with Vancomycin Hypersensitivity
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Choi Kyung-Ran
Yun Ju-Young
Kim Nam-Hee
Kang Hye-Ryun
Kang Dong-Yoon
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Abstract
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Vancomycin and teicoplanin are glycopeptide antibiotics used to treat severe gram-positive bacterial infections such as methicillin-resistant staphylococcus aureus. Several cross-reaction cases have been reported between these two drugs. A 61-year-old woman has a history of eosinophilia and systemic rash after vancomycin treatment. For the infection treatment of this patient, teicoplanin was chosen instead of vancomycin to avoid adverse drug reactions. However, neutropenia occurred after 8 days of teicoplanin administration. The neutropenia of this patient recovered after discontinuation of teicoplanin with administration of filgrastim. Clinicians should be aware of the possibility of cross-reaction between vancomycin and teicoplanin and be cautious in the treatment.
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KEYWORD
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Drug-Related side effects and adverse reactions, Cross reactions, Vancomycin, Teicoplanin, Neutropenia
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